Advanced TRPM8-Activating Cooling Agent for Pure, Odor-Free Sensory Refreshment

CryoCool™ delivers Menthyl Diisopropyl Propionamide (WS-23) — a next-generation cooling active engineered to activate skin cold receptors with up to 4× greater potency than menthol, while producing virtually zero odor, taste, or associated irritation. Where menthol delivers cooling alongside a strong characteristic aroma and potential mucous membrane sensitivity, WS-23 provides a pure, clean, and intense cold sensation with none of the sensory baggage.

The result: a highly controllable, formulation-compatible cooling experience ideal for scalp treatments, body care, after-sun, and premium sensory-enhanced skincare.

Why CryoCool™

• 4× more potent than menthol – activates TRPM8 cold receptors at significantly lower concentrations
• Zero menthol odor or taste – pure cooling sensation with no aromatherapy interference
• Exceptionally low use level – effective at 0.05–0.1%; cost-efficient and easy to titrate
• Versatile application – suitable for leave-on and rinse-off; scalp, body, and facial use
• Clean & globally compliant – synthetic, vegan, cruelty-free, EU Cosmetics Regulation compliant

Formulation Advantages

CryoCool™ is oil-soluble and can be dispersed in the oil phase of emulsions or pre-dissolved in a low-polarity solvent for aqueous incorporation. Stable across pH 3.0–8.0. At 0.05%, the cooling effect is already perceivable; adjust upward for more intense sensory profiles. A small quantity produces a dramatic and lasting effect.