Lamellar Delivery Technology for Enhanced Active Ingredient Bioavailability

Polyglyceryl-2 Triisostearate is an advanced polyglycerol ester emulsifier that goes beyond conventional emulsification to actively enhance the penetration and bioavailability of co-formulated active ingredients through the skin's lipid barrier.

By forming lamellar liquid crystalline structures whose bilayer architecture closely mirrors the intercellular lipid lamellae of the stratum corneum, it transiently increases lipid domain fluidity at the point of application — creating a temporary permeation pathway through which peptides, vitamins, and other actives can diffuse more efficiently into the viable epidermis and dermis.

Why Polyglyceryl-2 Triisostearate

• Enhances active ingredient delivery – lamellar structures increase transdermal flux of co-formulated actives
• Biomimetic bilayer architecture – mirrors the stratum corneum lipid organization for intelligent skin interaction
• Efficient W/O emulsifier – creates stable, sensory-elegant water-in-oil systems at low use levels
• Skin-conditioning – imparts a soft, silky, non-greasy finish that improves product aesthetics
• Clean & globally compliant – plant-derived polyglycerol ester, vegan, COSMOS-compatible

Formulation Advantages

Polyglyceryl-2 Triisostearate is oil-soluble with HLB ~3–4, making it ideal for W/O creams, oil serums, and lamellar liquid crystal delivery systems. At 1–3%, it creates stable, elegant emulsions without the high surfactant loads associated with conventional systems. Most impactful when formulating expensive actives such as peptides, retinoids, or Vitamin C derivatives where maximizing bioavailability is a priority.