Biomimetic Signal Peptide for Visibly Firmer, More Lifted Skin

PeptiFirm™ delivers Palmitoyl Tripeptide-5, a next-generation biomimetic peptide designed to activate the skin's own collagen synthesis pathway. By mimicking thrombospondin-1 (TSP-1), a key matrix glycoprotein, it engages TGF-β signaling in dermal fibroblasts — stimulating Type I and III collagen production while suppressing collagenase activity.

The palmitoyl modification ensures effective penetration through the lipid barrier, delivering the active peptide to its dermal target at remarkably low concentrations.

Why PeptiFirm™

• Activates TGF-β signaling – stimulates fibroblasts to produce Type I and III collagen at the source
• Visible firming & lifting – reduces wrinkle depth and improves skin elasticity with consistent use
• Suppresses collagen breakdown – inhibits MMP-1 (collagenase) activity to protect existing collagen
• High efficacy at low doses – effective at 3–10 ppm; highly cost-efficient in formulation
• Clean & globally compliant – synthetic, vegan, cruelty-free, suitable for all leave-on formats

Formulation Advantages

PeptiFirm™ is water-soluble and stable across pH 4.0–7.0. At use concentrations below 0.01%, it adds no viscosity, color, or odor and requires no special processing — integrating seamlessly into serums, eye creams, neck creams, and anti-aging moisturizers.